Ethics statement This study was carried out in strict accordance with the recommendations of the Guide for the Care and Use of Laboratory Animals of the Brazilian National Council of Animal Experimentation ( and the NIH Guidelines for the Care and Use of Laboratory Animals
4AF), These observations are consistent with a more homogeneous speckle-pattern in B-mode images since the relative contrast between neighboring pixels, per the GLCM algorithm, is smaller
Finally, GSH availability negatively regulates SLC25A39 protein abundance, coupling redox homeostasis to mitochondrial GSH import in mammalian cells
Intracellular ROS production Intracellular reactive oxygen species (ROS) levels were measured in treated cells using the oxidant-sensitive probe 2,7dichlorofluorescein diacetate [H 2 DCFDA] 11
Common symptoms include heavy menstrual bleeding (menorrhagia), iron deficiency anemia from blood loss, pelvic pressure or pain, abdominal distension, bladder frequency or incomplete emptying (anterior fibroids), constipation or rectal pressure (posterior fibroids), menstrual clotting, and, in some cases, recurrent pregnancy loss or difficulty conceiving
