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Methods Biomass preparation of Cocos nucifera (coconut), Syagrus coronata (licuri) and Terminalia catappa (almond) shells The green coconut husks (pericarp) and sea-almond fruits were obtained from wastes of local markets located in the city of Rio de Janeiro, Rio de Janeiro state (RJ), Brazil (22 53 48.391"S and 43 13 13.381"W), while Syagrus coronata (licuri) husks were obtained in the city of Caldeiro Grande, Brazil (11 1 9.584 S and 40 18 11.465 W)

Because the phytosome complex utilizes phosphatidylcholine, the silybin is highly lipid-soluble, allowing it to easily penetrate the lipid bilayer of the cell and anchor directly into the mitochondrial membranes