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Yamatani K, Watanabe T, Saito K, Maiti A, Yamashita S, Khasawneh A, Paran FJ, Hayes K, Borthakur G, Harman JR, Kimura S, DiNardo CD, Milne TA, Andreeff M , Tabe Y, and Konopleva MY

In colorectal cancer, NSUN2 enhances the stability of PHGDH mRNA through m5C methylation, thereby activating the SSP, increasing the intracellular NADH/NAD + and NADPH/NADP + ratios, reducing ROS levels and apoptosis, and promoting tumor cell survival and proliferation (105)

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CBGA, cannabigerolic acid

Challenges such as healthcare infrastructure, cost of biomarker testing, and access to high-quality supplements further complicate the implementation of precision supplementation strategies in these settings