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doi: 10.1016/j.numecd.2013.04.016 137 MinozziMCostantinoDGuaraldiCUnferV

While eNOS activation at optimal levels of BH 4 leads to production of NO, activation of NOS in the absence of or in the presence of decreased levels of BH 4 results in generation of superoxide rather than NO in the vascular endothelium

Life 14(2):244

It is not well recognized that plasma heme levels regulate the turnover of HPX ( i.e

Pharmacokinetics, Biodistribution, Immunogenicity, and Model-Informed-Based PK/PD Model of a Next-Generation Advanced Novel Gene Therapy for Hemophilia