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Do not skip doses or discontinue therapy prematurely, even if symptoms improve

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DNA Methyltransferase Inhibitors Upregulate CD38 Protein Expression and Enhance Daratumumab Efficacy in Multiple Myeloma

Both this subgroup and the 18 subjects with a normal Schilling test had low serum cobalamin concentrations at baseline, which increased significantly to normal range within 4 weeks of treatment [276 69 vs 96 15 pmol l 1 (CI 95% 130.5, 231.3)