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Description

This condition causes pain, numbness, and tingling in the hands and feet

Several risk genes encode voltage-gated calcium and chloride channels known to modulate glutamate receptor activity (CACNA1C and CLCN3), metabotropic receptors (glutamate (GRM1) and GABA (GABBR2)), and the NMDA-R subunit (GRIN2A)

Knowledge of the three-dimensional structures of MAOA and MAOB has provided new insights into the way in which MAO interacts with substrates and inhibitors, and has revealed intriguing species differences for MAOA