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Continuous improvements in oxidative stress markers, steatosis, and liver enzymes suggest a clinically significant benefit, even though not all metabolic parameters or body weight consistently dropped in some investigations

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doi: 10.1016/j.actatropica.2014.09.015 [DOI] [PubMed] [Google Scholar] 143

Therefore, when an antidepressant is stopped, or the dose is reduced, distinguishing withdrawal from a relapse of the original clinical problem is essential to avoid unnecessarily prolonged drug treatment, 35 as well as to prevent long-term harms (Table 2)