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Anatomical issues: Uterine shape problems, fibroids that distort the cavity, scar tissue (Ashermans syndrome), or a septate uterus can impair implantation or placental development

doi: 10.1016/j.jnutbio.2020.108486 171

51 Thus, according to these traditional pharmacological theories, these antidepressants always have the delayed clinical efficacy, this promises the potential new pharmacological mechanism still requires further study