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Br J Pharmacol

Inflammation and immune dysfunction in Parkinson disease

6.1.3 Complex I hypofunction stratification Multi-cohort and patient-derived data show that a biologically meaningful subset of idiopathic PD exhibits mitochondrial complex I deficiency aligned with higher ROS burden and clinical heterogeneity, supporting mitochondria-linked oxidative stress as a disease-relevantnot merely genericaxis (127)