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In clinical practice, the diagnosis of DVT requires a combination of clinical scores (e.g., Wells score), D-dimer testing, and imageological examination to evaluate the clinical predictive probability of DVT

Congenital errors of folate metabolism

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Disease-causing variants in the primary genes associated with low pyruvate dehydrogenase complex activity result in pyruvate dehydrogenase complex deficiency by interfering with pyruvate flux and energy production from carbohydrate oxidation with resultant lactic acidemia, hyperpyruvicemia, hyperalaninemia, and hyperprolinemia aggravated with consumption of carbohydrate