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2020 Nov 18;31(11):2564-2575

The GAA repeat sequence has been reported to bind to splicing factors such as those in the serine/arginine (SR)-rich protein family, and the proteins heterogeneous nuclear ribonucleoprotein (hnRNP) A1 and hnRNP A2, thereby rendering them incapable of splicing the introns during RNA processing ( FXN transcript, hence affecting the expression of the frataxin protein

Coenzyme found in all lifeforms, that is important for metabolism as an energy molecule.

Changes in the kinetic mechanism: depending on whether the concentration of drug is in the therapeutic or overdose range

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