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The efficacy of these pH-sensitive linkers is fundamentally reliant on the pronounced pH gradient between the neutral bloodstream and the acidic environments of pathogens, a gradient that is typically more stable and distinct than the fluctuations present in the tumor microenvironment (Onc-ADCs) ( 5.2 Pathogen-specific enzymatically cleavable linkers Linkers designed for cleavage by pathogen-specific enzymes exemplify the highest level of selectivity in antibody-drug conjugate design

[Google Scholar] Dayal, R

Nevertheless, in another study that used a rainbow trout cardiac fibrosis model, TIMP-2 and MMP9 transcript levels increased 24 h after receiving TGF-1 therapy (Johnston and Gillis 2017)

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