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Many human physiological processes produce reactive chemical molecules known as ROS which represents collections of broad ranges of radicals (oxidising agents) generated as by-products from oxygen metabolism due to impaired electron in the outer shell forming highly reactive molecule

S1C), suggesting that these mutants are more capable of sustaining this signalling cascade than the others in limited nutrient and growth factor conditions

Cataldo et al., 2020a)

ApTOLL, a DNA-binding aptamer, is an antagonist of TLR4 that reduces its activity and impedes its binding to DAMPs, thereby blocking the TLR4/MyD88/NF-kB pathway to attenuate the inflammatory cascade, and its efficacy has been demonstrated in preclinical phases (in rat cerebral ischemia/reperfusion animal models) (Fernndez et al., 2018), and it has demonstrated a superior safety profile in human phase I clinical trials (FIH I study) (Hernndez-Jimnez et al., 2022)

Genome-wide association study of obsessive-compulsive disorder