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J Clin Invest 132(12):e149371

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CJC without DAC activates GHRH receptors one trigger for GH release

Abbreviations 2-DG: 2-deoxy-D-glucose -KG: -ketoglutarate ART: Aspect ratio ASCL1: Achaete-scute homologue 1 CCLE: Cancer Cell Line Encyclopedia COX4I1: Cytochrome C Oxidase Subunit 4 Isoform 1 COX5B: Cytochrome C Oxidase Subunit 5B CPT1: Carnitine palmitoyltransferase 1 DAPI: 4,6-diamidino-2-phenylindole ECAR: Extracellular consumption rate EF: Elongation factor EMT: Epithelial-to-mesenchymal transition GDH: Glutamate dehydrogenase GLS: Glutaminase GSEA: Gene set enrichment analysis GSH: Glutathione GSSG: Glutathione disulfide HAD: 3 hydroxyacyl coenzyme A dehydrogenase HGB: Hemoglobin ICI: Immune checkpoint inhibitor IDH: Isocitrate dehydrogenase IHC: Immunohistochemistry LDH: Lactate dehydrogenase MPC: Mitochondrial pyruvate carrier NADH: Nicotinamide adenine dinucleotide ND1: NADH dehydrogenase 1 NDUFA5: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5 NE: Neuroendocrine NES: Normalized enrichment score NEUROD1: Neurogenic differentiation factor 1 OCR: Oxygen consumption rate OXPHOS: Oxidative phosphorylation PBS: Phosphate-buffered saline POU2F3: POU class 2 homeobox 3 SCLC: Small cell lung cancer SCLC-AN: ASCL1/ NEUROD1 expressing SCLC SDH: Succinate dehydrogenase TCA: Tricarboxylic acid cycle TRX: Thioredoxin T2DM: Type II diabetes mellitus YAP1: Yes-associated protein 1 References Megyesfalvi Z, Gay CM, Popper H, Pirker R, Ostoros G, Heeke S et al

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