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Thus, inhibition of GLS induced oxidative stress and diminished ATP levels in hypoxic cells [39]

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metabolites in cluster 5, which were specifically increased in LPS-induced pneumonia, were mainly enriched in purine metabolism, arginine biosynthesis, the PPP, and pyrimidine metabolism, indicating the robust immune-cell activation in LPS-induced pneumonia

Whilst the NTS itself has been implicated as a critical regulator of meal size and satiation 32,33,34 , the hypothalamus acts in concert with brainstem and limbic pathways to integrate peripheral and central signals controlling appetite

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