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We are now caring for second and third generations of previous patients

10.1007/s13562-016-0385-3 121 PeetersN.GuidotA.VailleauF.VallsM

H.KaroliussenI.JostA

In agreement, a 1.4-fold faster CL and a 1.6-fold shorter MRT were calculated for GLP-1 LX compared to GLP-1 WT with gPKPDSim (Supplementary Table 4)

Regarding additional residues of ScGrx7 that could form an interaction site for GSH, we suggest Asp144 and Glu147 in helix 3 as well as the hydroxyl group of conserved Tyr110: First, helix 3 and Tyr110 are both replaced in enzymatically inactive glutaredoxins 11,12 (Fig