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261 Pyruvate kinase M2 (PKM2), another key glycolytic enzyme, is stabilized by the deubiquitinase USP20, making USP20 a potential therapeutic target

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Emerging evidence suggests that autophagy may significantly contribute to the pathogenesis of PCOS ( Beyond follicular dynamics, autophagy is essential for maintaining normal oocyte and granulosa cell function, as well as modulating insulin signaling ( e.g ., IL-1, IL-18), thereby mitigating chronic inflammation

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Front Endocrinol 9:35 Nakamura E, Otsuka F, Inagaki K, Miyoshi T, Matsumoto Y, Ogura K et al (2012) Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells

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