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A comprehensive economic analysis was conducted and revealed that all replacement levels provided superior margins compared to the control group, with optimum economic result for the 50% replacement in this case (Figure 3)

Small linear peptides with no protective modifications are vulnerable to degradation at the injection site before absorption

The functional distinction between the enzymes terminal extensions is further demonstrated by structural analyses: the N-terminal extension seems to maximize substrate binding in alkaline environments through better cavity interactions and structural stabilization, whereas the C-terminal extension improves acid tolerance

Nat Rev Rheumatol (2020) 16:668

Death rates (DR) varied from 0.22/ 100,00 (Argentina) to 15.1/100,000 (Chinese Taipei)