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doi:10.1007/s00441019030168

One 2023 study in Circulation even found that clearing senescent cells, including with FOXO4-DRI, worsened pulmonary hypertension in rodents

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Pros and Cons Pros Accelerates healing across multiple tissue types Non-hormonal (doesnt disrupt the endocrine system) Targets both acute injuries and chronic conditions Can be used locally or systemically Generally well-tolerated with minimal side effects Works synergistically with TB-500 for enhanced healing Cons Limited large-scale human clinical trials Regulatory status varies by country The injectable form requires a proper administration technique Quality can vary between suppliers Optimal dosing protocols are still being established Who Should Use BPC-157