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The observed therapeutic effect indicated the need for early initiation of immunotherapy, aiming for rapid disease control to ameliorate tissue damage, since a biochemical shift may be mediated even in a few weeks from treatment onset, as shown in the present study

Leucine serine lysine leucine (LSKL) peptide therapy for blocking thrombospondin-1 (TSP-1), an activator of latent TGF-, was also shown to effectively reduce fibrosis and the development of hypertrophic scars [81]

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According to this paper by technology consultants West Monroe, while the overall framework developed by the PCS has been well-designed to account for the many inter-related moving parts, in practice, some areas, such as rate design, may be moving too slowly and falling out of sync with the others