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Intracellular accumulation not only injures mitochondria but also impairs autophagic flux, suppressing mitophagy and creating a damaging feedback loop that intensifies mitochondrial dysfunction and neurotoxicity (Zhao et al., 2023)

The combination of abemaciclib, a potent and selective orally bioavailable inhibitor of CDK4 and CDK6 (CDK4/6i), with endocrine therapy has been shown to significantly improve clinical outcomes compared to endocrine therapy alone in patients diagnosed with advanced ER + /HER2 breast cancer [4]