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doi: 10.3389/fonc.2017.00306 Received 18 October 2017 Accepted 28 November 2017 Published 11 December 2017 Volume 7 - 2017 Edited by Cristina Mazzoni, Sapienza Universit di Roma, Italy Reviewed by Marco Vanoni, Universit degli studi di Milano Bicocca, Italy