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Sulfur modification in natural RNA and therapeutic oligonucleotides

338 A-357300, which was subsequently developed, has shown anticancer activity in mouse models of cancer, sarcoma, and nervous system tumors, 339,340 and another candidate, METAPi A-800141, which was selected based on affinity selection based on mass spectrometry, has better selectivity and efficacy than A-357300

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intact milk protein concentrate and two hydrolysate whey protein concentrates with 32 and 45 % degrees of hydrolysis) before and after simulated gastrointestinal digestion and determined whether the plasma antioxidant capacity was similarly modified in vivo following acute ingestion (after 3 h) of these matrices in healthy 50- to 70-year-old women