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Moreover, both alcohol and MASLD disrupt intestinal barrier integrity, leading to endotoxemia and bacterial translocationkey drivers of hepatic inflammation through Toll-like receptor 4 (TLR4) activation and transformation of hepatic stellate cells into myofibroblastic phenotypes [66]

Methods: The study sample comprised 993 adults (Females 68%)

In HFD-fed mice, the treatment demonstrated improvements in glucose tolerance, reduced hepatic steatosis, and alleviated adipose inflammation, partially by restoring oxidative stress, inflammation, and ERSrelated gene expression through SIRT1 (Yoshino et al