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SKU: 61801339628 · From creatorsinfotech.com

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10.1172/jci.insight.151981 211 Marek-IannucciS.YildirimA

Moreover, the hepatic mRNA expression of the adhesion molecules Itgv and Itg6, which are expressed in PSC patients and activate TGF (a master regulator of fibrosis), were significantly increased following LCA treatment

In addition, inflammatory mediators such as PGE2 and LTB4 produced by Arachidonic acid and its derivatives catalyzed by cycoperoxidase can recruit and activate T cells to participate in inflammation (87).Therefore, arachidonic acid and its derivatives may play a key role in the pathogenesis of psoriasis by influencing the function and sensitivity of T cells and activating the inflammatory response