foxo4-dri apoptosis Tools to eliminate senescent cells History | Cleara Biotech
History Cleara Biotech Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv Peptide Inhibitors Targeting FOXO4 p53 Interactions and Inducing Senescent Cancer Cell specific Apoptosis Journal of Medicinal Chemistry The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. Molecular models of the FOXO4:p53 DBD and FOXO4 DRI: p53 DBD complexes. Download Scientific Diagram
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