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Hyperglycemia-induced PKC activation also results in increased platelet derived growth factor receptor expression on smooth muscle cells and other vascular wall cells increased expression of TGF-P is thought to lead to thickening of capillary basement membrane, one of the early structural abnormalities observed in almost all tissues in diabetes (Gould and Newton, 2008)

In AD, level of Tau methylation at K254 exceeds its ubiquitination level in PHFs, hampering the clearance of Tau aggregates by ubiquitin proteasomal system (UPS) [25]