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The peptide inhibitor can be delivered conveniently via intranasal administration and is shown to reduce brain amyloid deposition and ameliorate cognitive decline in Alzheimer transgenic mice

Additionally, ROS controls the extravasation of leukocytes through the promotion of endothelial integrity disassembly and the expression and activation of CAMs (e.g., E-selectin, intercellular adhesion moleculeICAM1, vascular cell adhesion moleculeVCAM1)