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The unfolded protein response is an adaptive response that restores ER homeostasis by activating the three proximal sensors TF6 (activating transcription factor 6), PKR-like endoplasmic reticulum kinase, and inositol-requiring enzyme 1 (IRE1) under short and mild ER stress, but severe and prolonged ER stress activates downstream effectors, including JNK, CHOP (C/EBP homologous protein), and members of the cystathionine and Bcl2 families, leading to apoptosis [105,106]

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Single-cell RNA sequencing (scRNA-seq) was employed to investigate the expression and biological functions of biomarkers linked to metabolites

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