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Inflammatory factors, prostaglandins, bradykinin, and proteases upregulate these receptors in UC and CD patients (Csek et al., 2019)

An iScript cDNA synthesis kit (Bio-Rad, Hercules, CA) was used to amplify 1 g of RNA per reaction in a MyCycler thermal cycler (Bio-Rad)

By "stages of dementia" we mean, for example: Early Stage Dementia (Mild Cognitive Impairment), which may be characterized by language difficulties (vocabulary recall, shrinking vocabulary, fluency, etc.)

Acknowledgements We gratefully acknowledge the Central Laboratory of Jiangsu Provincial Hospital of Traditional Chinese Medicine and the Department of Basic Pharmacology for providing experimental facilities and technical support