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[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Miners JO, Robson RA, Birkett DJ

In another particular embodiment, the diagnostic method of the invention comprises determining in a sample from a subject the levels of at least one marker as defined in Table 6

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In GCLC-deficient T cells, excessive ROS accumulation due to impaired GSH biosynthesis inhibits calcineurin function, thus suppressing NFAT activation and impairing T cell metabolic reprogramming