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Several trials on other NMDA-modulating drugs, including ketamine, 504 riluzole, 44,505 and d-cycloserine, 506 have been negative for the primary endpoint, indicating that further studies with increased sample sizes are required

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The most frequently reported adverse events were gastrointestinal events, including nausea, vomiting, diarrhea, constipation, or abdominal pain, which affected 79.6% of participants in the cagrilintide-semaglutide group and 39.9% of those in the placebo group

One paper focuses on blood flow rescue and colon injury in ischemic colitis