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REDEFINE1 (Phase 3): Over 3,400 adults with obesity or overweight (no T2DM) lost 22.7% of baseline body weight after 68 weeks, versus 12% with cagrilintide alone, 16% with semaglutide alone, and 2.3% on placebo

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There is growing evidence that the microbiome may be critical for establishing, maintaining, and reversing obesity 14,15,16 , and that both diet composition and adiposity each contribute to modulation of the mouse gut microbiome profile 49