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Because depletion of GSH induces apoptosis due to excessive oxidative stress [91], normal glutamine metabolism plays a critical role in preventing apoptosis by providing glutamate required for maintaining normal GSH/GSSG ratio

Murphy, T, Ramai, D, Lai, J, Sullivan, K, and Grimes, C (2017)

Mao 1 , Todd Kellogg 1 and Julie Heimbach 1 , (1)Mayo Clinic, (2)Johns Hopkins, (3)Mayo Clinic, Rochester, MN, (4)Mayo Clinic Arizona, Phoenix, AZ Background: The prevalence of obesity and metabolic syndrome (MS) is rising dramatically among liver transplant (LT) candidates, many of whom have NASH

In some cases, goiter size can shrink significantly with Se supplementation alone, especially in those with both iodine and Se deficiencies

While often used interchangeably in discussion, their biochemical properties and primary research applications can differ