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The SURMOUNT-1 Phase 3 trial published in the New England Journal of Medicine demonstrated 20.9% mean body weight reduction at 72 weeks on tirzepatide 15mg weekly versus 3.1% with placebo

The selectivity is between white fat and other tissues, not between different fat deposits

Research models indicate significant improvements in exercise capacity and mitochondrial density

These early findings open pathways for future investigation into how fat metabolism peptides might intersect with cardiovascular disease models

No elevation of IGF-1 Growth hormone works partly through stimulating insulin-like growth factor 1 (IGF-1) production in the liver