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The interplay between hyperandrogenemia and metabolic disturbances, such as insulin resistance and obesity, exacerbates the PCOS phenotype

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Recent Mendelian randomization findings further validate this framework: Dorea and Sellimonas appear protective, whereas Phascolarctobacterium and Ruminococcaceae UCG-004 are associated with increased PTSD risk (He et al., 2024)

Data availability All data generated in this study are provided in the Article, Supplementary Information, Supplementary Data and Source Data file

Advances in siRNA therapeutics and synergistic effect on siRNA activity using emerging dual ribose modifications