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A preclinical study showed that V-9302 could selectively block Gln uptake by TNBC cells, promote the activation of CD4 + T cells and CD8 + T cells, and reduce the level of Treg in a TNBC mouse model

Subsequently, western blot analysis was employed to assess the impact of Hspa1a knockdown on ER stress in KK1 cells in this experiment

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for example, inhibiting a disease, condition or disorder in an individual who is experiencing or displaying the pathology or symptomatology of the disease, condition or disorder (i.e., arresting further development of the pathology and/or symptomatology)

doi: 10.3389/fphar.2026.1801474 Received 01 February 2026 Revised 27 April 2026 Accepted 28 April 2026 Published 19 May 2026 Volume 17 - 2026 Edited by Sarmistha Saha, GLA University, India Reviewed by Aron Weller, Bar-Ilan University, Israel Muhammad Asim, Stanford University, United States Updates Copyright 2026 Pilatti, Philippsen, Bertollo, Webler, Bordignon and Igncio