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Key Points The drugs that were known to be effective for the treatment of depression during the 1960s and 1970s were inhibitors of monoamine oxidase, which degraded the monoamines, or tricyclic antidepressants, which inhibited the uptake of monoamines

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Senolytic therapies like FOXO4-DRI may offer a promising approach to modulate aging and halt neurodegenerative disease progression (4)

Their primary objectives include enhancing bioavailability, improving targeting efficiency, and enabling controlled release profiles to maximize therapeutic efficacy while minimizing off-target toxicity (Garhwal et al., 2024)