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J Invest Dermatol (1999) Skin care benefits of copper peptide containing facial cream Leyden JJ, Stevens T, Finkey MB

Gastroenterology 159(1):335349 Aruna R, Geetha A, Suguna P (2014) Rutin modulates ASC expression in NLRP3 inflammasome: a study in alcohol and cerulein-induced rat model of pancreatitis

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Importantly, this imbalance may arise from either increased ROS generation (i.e., via iron) and/or depletion of antioxidant defence (by glutathione depletion), with the latter given less weight in terms of being a cause of ferroptosis in diseases such as Alzheimers and Parkinsons where iron elevation is a signature (Figure 1)