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Availability: InStock
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SKU: 62988397183 · From creatorsinfotech.com

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& Zandman-Goddard, G

Oncogenic RIT1 mutations not only activate canonical RAS/MAPK and PI3K/AKT pathways but also modulate nuclear factor, erythroid 2 like 2 (NRF2) target expression, markedly increasing cellular susceptibility to ferroptosis inducers (33)

This leads to mitochondrial metabolic disorders, affecting ATP production, activating kinases to produce O 2 - , triggering oxidative stress, and further damaging mitochondria [204]