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In the same manner as Sublocade, and as explained in the coding announcement for HCPCS codes J0577 and J0578, [502] because all versions of a single source drug or biological product (or NDCs) marketed under the same FDA approval number are considered the same drug or biological for purposes of payments made under section 1847A of the Act, the payment limits for both J0577 and J0578 are calculated using all the NDCs marketed under the applicable FDA approval

With age, oxidative DNA damage increases, leading to excessive PARP-1 activation which depletes NAD+ reserves

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