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The HPA axis is involved in many psychopathological processes, such as depression, and long-term amphetamine abuse can damage the HPA axis, leading to impaired negative feedback, adrenal enlargement, and hypercortisolemia 39,40

Trazodone belongs to a class of medications called serotonin modulators, which means they work by altering the activity of post-synaptic serotonin receptors and by inhibiting the re-uptake of serotonin

There was no significant association between white matter hyperintensity burden and CSVD features such as lacunes and enlarged perivascular spaces and pial collateral supply

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Amouri S.S.E., Waker C.A., Huang L., Smith C.L., Mayes D.A