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6 New approaches in melasma pharmacotherapy Various adverse drug reactions are associated with systemic treatment and also numerous challenges are existing regarding the skin penetration and clinical efficacy of the topical conventional formulations that are considered in melasma management

EOs have shown significant potential in sun protection due to their ability to absorb UV radiation while scavenging free radicals, ultimately reducing photodamage and delaying skin aging

GST helps to manage free radical damage in multiple contexts [8,9]

Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions

Even out of the context of COVID-19, inflammation has been tightly intertwined with altered iron homeostasis [298]