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For example, VEGFA induces ROS in endothelial cells in a NADPH oxidase/rac1dependent manner that lead to autophosphorylation of the VEGFA receptor Flk1 and downstream activation of AKT and ERK, resulting in increased endothelial cell migration and proliferation, and antioxidants inhibited the mitogenic effects of VEGFA in endothelial cells (Abid et al , 2000

J Neural Transm (Vienna) 124:15671605 Fanciulli A, Campese N, Wenning GK (2019) The Schellong test: detecting orthostatic blood pressure and heart rate changes in German-speaking countries

Both DNA and mRNA vaccines fall under this category and are being pursued in the context of the COVID-19 pandemic

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However, we acknowledge that studies with conflicting or non-replicable findings are equally important and should be included in comprehensive future analyses