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Inhibitors of isoenzyme CYP 2D such as amiodarone, cimetidine, clomipramine and haloperidol may decrease the metabolism of tramadol thus reducing the levels of metabolite M1 and, consequently, the analgesic effectiveness, and increasing the appearance of adverse reactions

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Typical versions have between 100 and 300 milligrams per serving, but the exact dose depends on the health effect wanted and the people who will be taking it