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The 143B cells were cultured to 80% confluence, and incubated with 200 M hypoxyprobe and PBS, Ru(II)-OH, NP2, or NP4 (Ru 10 M) under hypoxia condition for 12 h

Higher scores indicated more severe degeneration [1]

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235 These findings provide evidence of increased ROS, decreased adiponectin, insulin resistance, and glucose intolerance due to adipocyte iron overload