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Description

Duan M, Ma N-N, Li D, Deng Y-S, Kong F-Y, Lv W, Meng Q-W (2012) Antisense-mediated suppression of tomato thylakoidal ascorbate peroxidase influences anti-oxidant network during chilling stress

The usual course of treatment doesnt work effectively on them

According to the invention, a library is generated by subjecting to reassembly (&/or one or more additional directed evolution methods described herein) random DNA (e.g., fragments of human, murine, or other genomic DNA), oligonucleotides that contain known ISS, poly A, C, G or T sequences, or combinations thereof

doi:10.1056/NEJM199007053230101

The most reasonable choice depends on the clinical objective, formulation quality, route, tolerance, convenience and evidence proportional to the claim being made