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HoferTMarzettiEXuJSeoAGulecSKnutsonMet alIncreased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy

Action GSH protects tissues by neutralizing free radicals, and improves the immune system by promoting antigen presentation and stimulating CD8 cells

Thus, it possesses only a limited spectrum of MS-relevant mechanisms in particular in lesion induction

Therefore, although both nonenzymatic and enzymatic succinylations occur on GCLC, the latter mediated by P300, in cooperation with SIRT2, may play a major role in dynamically modulating the succinylation level of GCLC under stress condition

[DOI] [PubMed] [Google Scholar] Lange SC, Bak LK, Waagepetersen HS, Schousboe A, Norenberg MD