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J Psychopharmacol 2013;27(11):96771

Its binding constant (pKa 16.44) is similar to albumin's copper transport site (log = 16.2), allowing GHK to exchange copper with albumin for intracellular delivery.[3] Discovery and design rationale GHK was first identified in 1973 in fractions of human plasma that promoted survival of liver cells in culture

Moreover, the activation of parallel but interconnected signal transduction pathways in ES suggested a potential role for multi-pathway targeting of IGF-1R and mTOR [9496]