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and Escoubas, Pierre (2013)

This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function

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SHMT2 has been reported to be highly expressed in pseudopalisading cells surrounding ischemic necrotic foci in GBM, suppressing PKM2 activity and limiting pyruvate entry into the TCA cycle [30]

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